2025
- Pharmacologic inhibition of IRE1α-dependent decay protects alveolar epithelia identity and prevents pulmonary fibrosis in mice. Auyeung VC, Steinberg TL, Olivier A, Suzuki L, Moreno ME, Khan IS, Downey MS, Thamsen M, Guo L, Maly DJ, Backes BJ, Sheppard D, Papa FR. J Clin Invest. 2025 Oct 15;135(20):e184522. doi:10.1172/JCI184522. eCollection 2025 Oct 15. PMID:41090357.
2022
- IRE1α drives lung epithelial progenitor dysfunction to establish a niche for pulmonary fibrosis. Auyeung VC, Downey MS, Thamsen M, Wenger TA, Backes BJ, Sheppard D, Papa FR. AM J Physiol Lung Cell Mol Physiol. 2022 04 01; 322(4):L564-L580. PMID:35170357. PMCID:PMC8957349.
2021
- ATP-competitive partial antagonists of the IRE1α RNase segregate outputs of the UPR. Feldman HC, Ghosh R, Auyeung VC, Mueller JL, Kim JH, Potter ZE, Vidadala VN, Perera BGK, Olivier A, Backes BJ, Zikherman J, Papa FR, Maly DJ. Nat Chem Biol. 2021 Nov 17. doi: 10.1038/s41589-021-00852-0. PMID: 34556859. PMCID: PMC8551014.
2019
Small Molecules to Improve ER Proteostasis in Disease. Gonzalez-Teuber V, Albert-Gasco H, Auyeung VC, Papa FR, Mallucci GR, Hetz C. Trends Pharmacol Sci, 2019, Sep, 40(9), p684-95, PMID: 31377018.
- Chaperone-mediated reflux of secretory proteins to the cytosol during endoplasmic reticulum stress. Igbaria A, Merksamer PI, Trusina A, Tilahun F, Johnson JR, Brandman O, Krogan NJ, Weissman JS, Papa FR. Proc Natl Acad Sci U S A, 2019, Jun 4, 116(23), p11291-8, PMID: 31101715, PMCID: PMC6561268.
- Small molecule inhibition of IRE1alpha kinase/RNase has anti-fibrotic effects in the lung. Thamsen M, Ghosh R, Auyeung VC, Brumwell A, Chapman HA, Backes BJ, Perara G, Maly DJ, Sheppard D, Papa FR.. J Clin Invest. 2025 Oct 15;135(20):e184522. doi:10.1172/JCI184522. eCollection 2025 Oct 15. PMID:41090357.
- Parallel Signaling through IRE1alpha and PERK Regulates Pancreatic Neuroendocrine Tumor Growth and Survival. Moore PC, Qi JY, Thamsen M, Ghosh R, Peng J, Gliedt MJ, Meza-Acevedo R, Warren RE, Hiniker A, Kim GE, Maly DJ, Backes BJ, Papa FR, Oakes SA. Parallel Signaling through IRE1α and PERK Regulates Pancreatic Neuroendocrine Tumor Growth and Survival. Cancer Res. 2019 Dec 15;79(24):6190-6203. doi: 10.1158/0008-5472.CAN-19-1116. Epub 2019 Oct 31. PMID: 31672843; PMCID: PMC6911642.
2018
- The Unfolded Protein Response and Cell Fate Control. Hetz C, Papa FR. Mol Cell, 2018, Jan 18, 69(2), p169-81, PMID: 29107536.
2017
- Targeting ABL-IRE1alpha Signaling Spares ER-Stressed Pancreatic beta Cells to Reverse Autoimmune Diabetes.Morita S, Villalta SA, Feldman HC, Register AC, Rosenthal W, Hoffmann-Petersen IT, Mehdizadeh M, Ghosh R, Wang L, Colon-Negron K, Meza-Acevedo R, Backes BJ, Maly DJ, Bluestone JA, Papa FR. Cell Metab, 2017, Apr 4, 25(4), p883-97.e8, PMID: 28380378, PMCID: PMC5497784.
2016
- Structural and Functional Analysis of the Allosteric Inhibition of IRE1alpha with ATP-Competitive Ligands. Feldman HC, Tong M, Wang L, Meza-Acevedo R, Gobillot TA, Lebedev I, Gliedt MJ, Hari SB, Mitra AK, Backes BJ, Papa FR, Seeliger MA, Maly DJ. ACS Chem Biol, 2016, Aug 19, 11(8), p2195-205, PMID: 27227314, PMCID: PMC4992410.
2014
Allosteric Inhibition of the IRE1α RNase Preserves Cell Viability and Function during Endoplasmic Reticulum Stress. Ghosh R, Wang L, Wang ES, Perera BG, Igbaria A, Morita S, Prado K, Thamsen M, Caswell D, Macias H, Weiberth KF, Gliedt MJ, Alavi MV, Hari SB, Mitra AK, Bhhatarai B, Schürer SC, Snapp EL, Gould DB, German MS, Backes BJ, Maly DJ, Oakes SA, Papa FR. Cell. 2014 Jul 31;158(3):534-48. doi: 10.1016/j.cell.2014.07.002. Epub 2014 Jul 10. PMID: 25018104.
- Druggable sensors of the unfolded protein response. Maly DJ. Papa FR. Nat Chem Biol. 2014 Nov; 10(11):892-901. doi: 10.1038/nchembio.1664. PMID: 25325700; PMCID: PMC4664160.
2013
- Establishment of a system for monitoring endoplasmic reticulum redox state in mammalian cells. Kanekura K, Ishigaki S, Merksamer PI, Papa FR, Urano F. Lab Invest. 2013 Nov;93(11):1254-8. doi: 10.1038/labinvest.2013.112. Epub 2013 Sep 16. PMID: 24042438.
- X-box binding protein 1 (XBP1s) is a critical determinant of Pseudomonas aeruginosa homoserine lactone-mediated apoptosis. Valentine CD, Anderson MO, Papa FR, Haggie PM. PLoS Pathog. 2013;9(8):e1003576. doi: 10.1371/journal.ppat.1003576. Epub 2013 Aug 22. PMID: 23990788.
2012
- Cleaved cytokeratin-18 is a mechanistically informative biomarker in idiopathic pulmonary fibrosis. Cha SI, Ryerson CJ, Lee JS, Kukreja J, Barry SS, Jones KD, Elicker BM, Kim DS, Papa FR, Collard HR, Wolters PJ. Respir Res. 2012 Nov 20;13:105. doi: 10.1186/1465-9921-13-105. PMID: 23167970.
- Divergent allosteric control of the IRE1a endoribonuclease using kinase inhibitors. Wang L, Perera BG, Hari SB, Bhhatarai B, Backes BJ, Seeliger MA, Schürer SC, Oakes SA, Papa FR, Maly DJ. Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors. Nat Chem Biol. 2012 Dec;8(12):982-9. doi: 10.1038/nchembio.1094. Epub 2012 Oct 21. PMID: 23086298; PMCID: PMC3508346.
- IRE1α Cleaves Select microRNAs During ER Stress to Derepress Translation of Proapoptotic Caspase-2. Upton JP, Wang L, Han D, Wang E, Huskey N, Lim L, Truitt M, McManus M, Ruggero D, Goga A, Papa F, Oakes1 S. Science. IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2. Science. 2012 Nov 9;338(6108):818-22. doi: 10.1126/science.1226191. Epub 2012 Oct 4. PMID: 23042294; PMCID: PMC3742121.
- IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress. Lerner AG, Upton JP, Praveen PV, Ghosh R, Nakagawa Y, Igbaria A, Shen S, Nguyen V, Backes BJ, Heiman M, Heintz N, Greengard P, Hui S, Tang Q, Trusina A, Oakes SA, Papa FR. Cell Metab. 2012 Aug 8;16(2):250-64.
- Endoplasmic reticulum stress, pancreatic β-cell degeneration, and diabetes. Papa FR. Cold Spring Harb Perspect Med. 2012 Sept 1;2(9):a0077666. doi: 10.1101/cshperspect.a007666. PMID: 22951443; PMCID: PMC3426819.
2011
- Signaling cell death from the endoplasmic reticulum stress response. Shore GC, Papa FR, Oakes SA. Signaling cell death from the endoplasmic reticulum stress response. Curr Opin Cell Biol. 2011 Apr;23(2):143-9. doi: 10.1016/j.ceb.2010.11.003. Epub 2010 Dec 9. PMID: 21146390; PMCID: PMC3078187.
2010
- The UPR and cell fate at a glance. Merksamer PI, Papa FR. The UPR and cell fate at a glance. J Cell Sci. 2010 Apr 1;123(Pt 7):1003-6. doi: 10.1242/jcs.035832. PMID: 20332117; PMCID: PMC2844313.
2009
Spontaneous development of endoplasmic reticulum stress that can lead to diabetes mellitus is associated with higher calcium-independent phospholipase A2 expression: a role for regulation by SREBP-1. Lei X, Zhang S, Barbour SE, Bohrer A, Ford EL, Koizumi A, Papa FR, Ramanadham S. Spontaneous development of endoplasmic reticulum stress that can lead to diabetes mellitus is associated with higher calcium-independent phospholipase A2 expression: a role for regulation by SREBP-1. J Biol Chem. 2010 Feb 26;285(9):6693-705. doi: 10.1074/jbc.M109.084293. Epub 2009 Dec 23. PMID: 20032468; PMCID: PMC2825464.
- IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates. Han D, Lerner AG, Vande Walle L, Upton JP, Xu W, Hagen A, Backes BJ, Oakes SA, Papa FR. IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates. Cell. 2009 Aug 7;138(3):562-75. doi: 10.1016/j.cell.2009.07.017. PMID: 19665977; PMCID: PMC2762408.
2008
Rationalizing translation attenuation in the network architecture of the unfolded protein response. Trusina A, Papa FR, Tang C. Rationalizing translation attenuation in the network architecture of the unfolded protein response. Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20280-5. doi: 10.1073/pnas.0803476105. Epub 2008 Dec 15. PMID: 19075238; PMCID: PMC2603256.
- Real-time redox measurements during endoplasmic reticulum stress reveal interlinked protein folding functions. Merksamer PI, Trusina A, Papa FR. Real-time redox measurements during endoplasmic reticulum stress reveal interlinked protein folding functions. Cell. 2008 Nov 28;135(5):933-47. doi: 10.1016/j.cell.2008.10.011. Epub 2008 Nov 20. PMID: 19026441; PMCID: PMC2739138.
- Caspase-2 cleavage of BID is a critical apoptotic signal downstream of endoplasmic reticulum stress. Upton JP, Austgen K, Nishino M, Coakley KM, Hagen A, Han D, Papa FR, Oakes SA. Caspase-2 cleavage of BID is a critical apoptotic signal downstream of endoplasmic reticulum stress. Mol Cell Biol. 2008 Jun;28(12):3943-51. doi: 10.1128/MCB.00013-08. Epub 2008 Apr 21. PMID: 18426910; PMCID: PMC2423129.
- A kinase inhibitor activates the IRE1alpha RNase to confer cytoprotection against ER stress. Han D, Upton JP, Hagen A, Callahan J, Oakes SA, Papa FR. A kinase inhibitor activates the IRE1alpha RNase to confer cytoprotection against ER stress. Biochem Biophys Res Commun. 2008 Jan 25;365(4):777-83. doi: 10.1016/j.bbrc.2007.11.040. Epub 2007 Nov 21. PMID: 18035051.
2006
- Intracellular signaling by the unfolded protein response. Bernales S, Papa FR, Walter P. Intracellular signaling by the unfolded protein response. Annu Rev Cell Dev Biol. 2006;22:487-508. doi: 10.1146/annurev.cellbio.21.122303.120200. PMID: 16822172.
2005
- On the mechanism of sensing unfolded protein in the endoplasmic reticulum. Credle JJ, Finer-Moore JS, Papa FR, Stroud RM, Walter P. On the mechanism of sensing unfolded protein in the endoplasmic reticulum. Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):18773-84. doi: 10.1073/pnas.0509487102. Epub 2005 Dec 19. PMID: 16365312; PMCID: PMC1316886.
2003
- Bypassing a kinase activity with an ATP-competitive drug. Papa FR, Zhang C, Shokat K, Walter P. Bypassing a kinase activity with an ATP-competitive drug. Science. 2003 Nov 28;302(5650):1533-7. doi: 10.1126/science.1090031. Epub 2003 Oct 16. PMID: 14564015.