Publications

 

2014

Allosteric Inhibition of the IRE1α RNase Preserves Cell Viability and Function during Endoplasmic Reticulum Stress. Ghosh R, Wang L, Wang ES, Perera BG, Igbaria A, Morita S, Prado K, Thamsen M, Caswell D, Macias H, Weiberth KF, Gliedt MJ, Alavi MV, Hari SB, Mitra AK, Bhhatarai B, Schürer SC, Snapp EL, Gould DB, German MS, Backes BJ, Maly DJ, Oakes SA, Papa FR. Cell. 2014 Jul 31;158(3):534-48. doi: 10.1016/j.cell.2014.07.002. Epub 2014 Jul 10. PMID: 25018104 [PubMed - in process]

 

2013

Establishment of a system for monitoring endoplasmic reticulum redox state in mammalian cells. Kanekura K, Ishigaki S, Merksamer PI, Papa FR, Urano F. Lab Invest. 2013 Nov;93(11):1254-8. doi: 10.1038/labinvest.2013.112. Epub 2013 Sep 16. PMID: 24042438 [PubMed - indexed for MEDLINE]

X-box binding protein 1 (XBP1s) is a critical determinant of Pseudomonas aeruginosa homoserine lactone-mediated apoptosis. Valentine CD, Anderson MO, Papa FR, Haggie PM. PLoS Pathog. 2013;9(8):e1003576. doi: 10.1371/journal.ppat.1003576. Epub 2013 Aug 22. PMID: 23990788 [PubMed - indexed for MEDLINE]

2012

Cleaved cytokeratin-18 is a mechanistically informative biomarker in idiopathic pulmonary fibrosis. Cha SI, Ryerson CJ, Lee JS, Kukreja J, Barry SS, Jones KD, Elicker BM, Kim DS, Papa FR, Collard HR, Wolters PJ. Respir Res. 2012 Nov 20;13:105. doi: 10.1186/1465-9921-13-105. PMID: 23167970 [PubMed - indexed for MEDLINE]

Divergent allosteric control of the IRE1a endoribonuclease using kinase inhibitors. *Co-senior author. Wang L, Perera B, Hari S, Bhhatarai B, Backes1 B, Seeliger M, Schürer S, Oakes S, Papa F*, Maly D*. Nature Chemical Biology. 2012 October 21.

IRE1α Cleaves Select microRNAs During ER Stress to Derepress Translation of Proapoptotic Caspase-2. *Co-senior author. Upton JP, Wang L, Han D, Wang E, Huskey N, Lim L, Truitt M, McManus M, Ruggero D, Goga A, Papa F*, Oakes1 S*. Science. 2012 Oct 3. PDF

IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress. *Co-senior author. Lerner AG, Upton JP, Praveen PV, Ghosh R, Nakagawa Y, Igbaria A, Shen S, Nguyen V, Backes BJ, Heiman M, Heintz N, Greengard P, Hui S, Tang Q, Trusina A, Oakes SA*, Papa FR*. Cell Metab. 2012 Aug 8;16(2):250-64. PD

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Endoplasmic reticulum stress, pancreatic β-cell degeneration, and diabetes. Papa FR. Cold Spring Harb Perspect Med. 2012 Aug 14.

2011

Signaling cell death from the endoplasmic reticulum stress response. Shore GC, Papa FR, Oakes SA. Curr Opin Cell Biol. 2011 Apr;23(2):143-9. Epub 2010 Dec 9. Review.

2010

The UPR and cell fate at a glance. Merksamer PI, Papa FR. J Cell Sci. 2010 Apr 1;123(Pt 7):1003-6.

Spontaneous development of endoplasmic reticulum stress that can lead to diabetes mellitus is associated with higher calcium-independent phospholipase A2 expression: a role for regulation by SREBP-1. Lei X, Zhang S, Barbour SE, Bohrer A, Ford EL, Koizumi A, Papa FR, Ramanadham S. J Biol Chem. 2010 Feb 26;285(9):6693-705. Epub 2009 Dec 23.

2009

IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates. Han D, Lerner AG, Vande Walle L, Upton JP, Xu W, Hagen A, Backes BJ, Oakes SA, Papa FR. Cell. 2009 Aug 7;138(3):562-75.

2008

Rationalizing translation attenuation in the network architecture of the unfolded protein response. Trusina A, Papa FR, Tang C. Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20280-5. Epub 2008 Dec 15.

cellReal-time redox measurements during endoplasmic reticulum stress reveal interlinked protein folding functions. Merksamer PI, Trusina A, Papa FR. Cell. 2008 Nov 28;135(5):933-47. Epub 2008 Nov 20.

Caspase-2 cleavage of BID is a critical apoptotic signal downstream of endoplasmic reticulum stress. Upton JP, Austgen K, Nishino M, Coakley KM, Hagen A, Han D, Papa FR, Oakes SA. Mol Cell Biol. 2008 Jun;28(12):3943-51. Epub 2008 Apr 21.

A kinase inhibitor activates the IRE1alpha RNase to confer cytoprotection against ER stress. Han D, Upton JP, Hagen A, Callahan J, Oakes SA, Papa FR. Biochem Biophys Res Commun. 2008 Jan 25;365(4):777-83. Epub 2007 Nov 21.

2006

Intracellular signaling by the unfolded protein response. Bernales S, Papa FR, Walter P. Annu Rev Cell Dev Biol. 2006;22:487-508. Review.

2005

On the mechanism of sensing unfolded protein in the endoplasmic reticulum. Credle JJ, Finer-Moore JS, Papa FR, Stroud RM, Walter P. Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):18773-84. Epub 2005 Dec 19.

2003

Bypassing a kinase activity with an ATP-competitive drug. Papa FR, Zhang C, Shokat K, Walter P. Science. 2003 Nov 28;302(5650):1533-7. Epub 2003 Oct 16.