Publications

2019

• Small Molecules to Improve ER Proteostasis in Disease. Gonzalez-Teuber V, Albert-Gasco H, Auyeung VC, Papa FR, Mallucci GR, Hetz C.  Trends Pharmacol Sci, 2019, Sep, 40(9), p684-95, PMID: 31377018. 
  Gonzalez-Teuber et al._2019 .pdf
• Chaperone-mediated reflux of secretory proteins to the cytosol during endoplasmic reticulum stress. Igbaria A, Merksamer PI, Trusina A, Tilahun F, Johnson JR, Brandman O, Krogan NJ, Weissman JS, Papa FR.  Proc Natl Acad Sci U S A, 2019, Jun 4, 116(23), p11291-8, PMID: 31101715, PMCID: PMC6561268.  
  Igbaria et al PNAS_2019.pdf
• Small molecule inhibition of IRE1alpha kinase/RNase has anti-fibrotic effects in the lung.Thamsen M, Ghosh R, Auyeung VC, Brumwell A, Chapman HA, Backes BJ, Perara G, Maly DJ, Sheppard D, Papa FR.  PLoS One, 2019, 14(1), pe0209824, PMID: 30625178, PMCID: PMC6326459. 
  Maike et al_2019.pdf
• Parallel Signaling through IRE1alpha and PERK Regulates Pancreatic Neuroendocrine Tumor Growth and Survival. Moore PC, Qi JY, Thamsen M, Ghosh R, Peng J, Gliedt MJ, Meza-Acevedo R, Warren RE, Hiniker A, Kim GE, Maly DJ, Backes BJ, Papa FR, Oakes SA.  Cancer Res, 2019, Dec 15, 79(24), p6190-203, PMID: 31672843, PMCID: PMC6911642. 
  Moore et al_2019.pdf

2018

• The Unfolded Protein Response and Cell Fate Control. Hetz C, Papa FR. Mol Cell, 2018, Jan 18, 69(2), p169-81, PMID: 29107536. 
  Hetz and Papa_2018.pdf

2017

• Targeting ABL-IRE1alpha Signaling Spares ER-Stressed Pancreatic beta Cells to Reverse Autoimmune Diabetes.Morita S, Villalta SA, Feldman HC, Register AC, Rosenthal W, Hoffmann-Petersen IT, Mehdizadeh M, Ghosh R, Wang L, Colon-Negron K, Meza-Acevedo R, Backes BJ, Maly DJ, Bluestone JA, Papa FR.  Cell Metab, 2017, Apr 4, 25(4), p883-97.e8, PMID: 28380378, PMCID: PMC5497784.
  Morita_Cell Metabolism_2017.pdf

2016

• Structural and Functional Analysis of the Allosteric Inhibition of IRE1alpha with ATP-Competitive Ligands. Feldman HC, Tong M, Wang L, Meza-Acevedo R, Gobillot TA, Lebedev I, Gliedt MJ, Hari SB, Mitra AK, Backes BJ, Papa FR, Seeliger MA, Maly DJ. ACS Chem Biol, 2016, Aug 19, 11(8), p2195-205, PMID: 27227314, PMCID: PMC4992410. 
  Feldman et al_2016.pdf

2014

• Allosteric Inhibition of the IRE1α RNase Preserves Cell Viability and Function during Endoplasmic Reticulum Stress. Ghosh R, Wang L, Wang ES, Perera BG, Igbaria A, Morita S, Prado K, Thamsen M, Caswell D, Macias H, Weiberth KF, Gliedt MJ, Alavi MV, Hari SB, Mitra AK, Bhhatarai B, Schürer SC, Snapp EL, Gould DB, German MS, Backes BJ, Maly DJ, Oakes SA, Papa FR. Cell. 2014 Jul 31;158(3):534-48. doi: 10.1016/j.cell.2014.07.002. Epub 2014 Jul 10. PMID: 25018104 [PubMed - in process]
  Cell2014.pdf
• Druggable sensors of the unfolded protein response. Maly DJ. Papa FR 
  Maly and Papa_2014.pdf

2013

• Establishment of a system for monitoring endoplasmic reticulum redox state in mammalian cells. Kanekura K, Ishigaki S, Merksamer PI, Papa FR, Urano F. Lab Invest. 2013 Nov;93(11):1254-8. doi: 10.1038/labinvest.2013.112. Epub 2013 Sep 16. PMID: 24042438 [PubMed - indexed for MEDLINE]
  LA2013.pdf
• X-box binding protein 1 (XBP1s) is a critical determinant of Pseudomonas aeruginosa homoserine lactone-mediated apoptosis. Valentine CD, Anderson MO, Papa FR, Haggie PM. PLoS Pathog. 2013;9(8):e1003576. doi: 10.1371/journal.ppat.1003576. Epub 2013 Aug 22. PMID: 23990788 [PubMed - indexed for MEDLINE]
  PLOS2013.pdf

2012

• Cleaved cytokeratin-18 is a mechanistically informative biomarker in idiopathic pulmonary fibrosis. Cha SI, Ryerson CJ, Lee JS, Kukreja J, Barry SS, Jones KD, Elicker BM, Kim DS, Papa FR, Collard HR, Wolters PJ. Respir Res. 2012 Nov 20;13:105. doi: 10.1186/1465-9921-13-105. PMID: 23167970 [PubMed - indexed for MEDLINE]
  RR2012.pdf
• Divergent allosteric control of the IRE1a endoribonuclease using kinase inhibitors. *Co-senior author. Wang L, Perera B, Hari S, Bhhatarai B, Backes1 B, Seeliger M, Schürer S, Oakes S, Papa F*, Maly D*. Nature Chemical Biology. 2012 October 21.
  nchembio.pdf
• IRE1α Cleaves Select microRNAs During ER Stress to Derepress Translation of Proapoptotic Caspase-2. *Co-senior author. Upton JP, Wang L, Han D, Wang E, Huskey N, Lim L, Truitt M, McManus M, Ruggero D, Goga A, Papa F*, Oakes1 S*. Science. 2012 Oct 3. PDF
• IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress. *Co-senior author. Lerner AG, Upton JP, Praveen PV, Ghosh R, Nakagawa Y, Igbaria A, Shen S, Nguyen V, Backes BJ, Heiman M, Heintz N, Greengard P, Hui S, Tang Q, Trusina A, Oakes SA*, Papa FR*. Cell Metab. 2012 Aug 8;16(2):250-64. PD
  Lerner2012.pdf
  F (See press release here)
• Endoplasmic reticulum stress, pancreatic β-cell degeneration, and diabetes. Papa FR. Cold Spring Harb Perspect Med. 2012 Aug 14.
  Papa2012.pdf

2011

• Signaling cell death from the endoplasmic reticulum stress response. Shore GC, Papa FR, Oakes SA. Curr Opin Cell Biol. 2011 Apr;23(2):143-9. Epub 2010 Dec 9. Review.
  Shore2011.pdf

2010

• The UPR and cell fate at a glance. Merksamer PI, Papa FR. J Cell Sci. 2010 Apr 1;123(Pt 7):1003-6.
  Merksamer2010.pdf
• Spontaneous development of endoplasmic reticulum stress that can lead to diabetes mellitus is associated with higher calcium-independent phospholipase A2 expression: a role for regulation by SREBP-1. Lei X, Zhang S, Barbour SE, Bohrer A, Ford EL, Koizumi A, Papa FR, Ramanadham S. J Biol Chem. 2010 Feb 26;285(9):6693-705. Epub 2009 Dec 23.
  Lei2009.pdf

2009

• IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates. Han D, Lerner AG, Vande Walle L, Upton JP, Xu W, Hagen A, Backes BJ, Oakes SA, Papa FR. Cell. 2009 Aug 7;138(3):562-75.
  Han2009.pdf

2008

• Rationalizing translation attenuation in the network architecture of the unfolded protein response. Trusina A, Papa FR, Tang C. Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20280-5. Epub 2008 Dec 15.
  Trusina2008.pdf
• Real-time redox measurements during endoplasmic reticulum stress reveal interlinked protein folding functions. Merksamer PI, Trusina A, Papa FR. Cell. 2008 Nov 28;135(5):933-47. Epub 2008 Nov 20.
  Merksamer2008.pdf
• Caspase-2 cleavage of BID is a critical apoptotic signal downstream of endoplasmic reticulum stress. Upton JP, Austgen K, Nishino M, Coakley KM, Hagen A, Han D, Papa FR, Oakes SA. Mol Cell Biol. 2008 Jun;28(12):3943-51. Epub 2008 Apr 21.
  Upton2008.pdf
• A kinase inhibitor activates the IRE1alpha RNase to confer cytoprotection against ER stress. Han D, Upton JP, Hagen A, Callahan J, Oakes SA, Papa FR. Biochem Biophys Res Commun. 2008 Jan 25;365(4):777-83. Epub 2007 Nov 21.
  Han2008.pdf

2006

• Intracellular signaling by the unfolded protein response. Bernales S, Papa FR, Walter P. Annu Rev Cell Dev Biol. 2006;22:487-508. Review.
  Bernales2006.pdf

2005

• On the mechanism of sensing unfolded protein in the endoplasmic reticulum. Credle JJ, Finer-Moore JS, Papa FR, Stroud RM, Walter P. Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):18773-84. Epub 2005 Dec 19.
  Credle2005.pdf

2003

• Bypassing a kinase activity with an ATP-competitive drug. Papa FR, Zhang C, Shokat K, Walter P. Science. 2003 Nov 28;302(5650):1533-7. Epub 2003 Oct 16.
  Papa2003.pdf